Risk factors and outcome for breakthrough candidaemia in patients with cancer.
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| Abstract |
While candidaemia that develops during systemic antifungal prophylaxis or therapy [breakthrough (BT) candidaemia] has been reported increasingly, the risk factors and outcome of BT candidaemia are not yet known definitely. We evaluated a consecutive series of cancer patients with candidaemia at Asan Medical Center during 6 years to identify risk factors and outcome in BT candidaemia comparing with non-BT candidaemia. Fifty-four episodes of candidaemia in cancer patients diagnosed during this period were reviewed retrospectively. There were 10 episodes (18.5%) of BT candidaemia in which the species distribution and frequency of catheter-related infection in the BT and non-BT groups were similar. BT candidaemia had a tendency to occur more frequently in patients with haematological than non-haematological diseases. Profound neutropenia and disseminated candidiasis were more common in the BT group; however, these differences were not statistically significant (P = 0.17 and 0.07 respectively). The duration of prior antibiotic therapy and duration of profound neutropenia (<100 mm(-3)) were identified as risk factors for BT candidaemia (P < 0.01 and 0.02 respectively) in univariate analysis and the latter was the only risk factor in multivariate analysis. The death rates due to candidaemia were 85.7% in the BT group and 42.9% in the non-BT group (P = 0.08); however, BT candidaemia alone did not increase mortality rate.
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| Authors | Jin-Won Chung, Sang-Oh Lee, Sang-Ho Choi, Jun-Hee Woo, Jiso Ryu, Yang Soo Kim, Nam Joong Kim |
| Journal | Mycoses (Mycoses) Vol. 49 Issue 2 Pg. 114-8 (Mar 2006) ISSN: 0933-7407 [Print] Germany |
| PMID | 16466444 (Publication Type: Journal Article) |
| Chemical References |
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