Abstract | OBJECTIVE: DESIGN: Open-label study. SETTING: Three university medical centers. PATIENTS: Five patients with AIDS who were infected with thymidine-kinase-deficient or -altered strains of varicella-zoster virus. INTERVENTION: MAIN RESULTS: Four patients had healing in response to foscarnet therapy, and each of four tested patients became culture negative for virus during foscarnet therapy. Results of fluorescent antigen testing remained positive during therapy in two patients; one of these patients had concomitant clinical failure but the other patient healed fully. One patient had complete healing despite the emergence of resistance to foscarnet in serial specimens obtained during foscarnet therapy. CONCLUSION:
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Authors | S Safrin, T G Berger, I Gilson, P R Wolfe, C B Wofsy, J Mills, K K Biron |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 115
Issue 1
Pg. 19-21
(Jul 01 1991)
ISSN: 0003-4819 [Print] United States |
PMID | 1646585
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- Foscarnet
- Phosphonoacetic Acid
- Acyclovir
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Topics |
- Acquired Immunodeficiency Syndrome
(complications)
- Acyclovir
(therapeutic use)
- Adult
- Antiviral Agents
(adverse effects, therapeutic use)
- Cohort Studies
- Drug Resistance, Microbial
- Foscarnet
- Herpes Zoster
(drug therapy, etiology, microbiology)
- Herpesvirus 3, Human
(drug effects, isolation & purification)
- Humans
- Middle Aged
- Phosphonoacetic Acid
(adverse effects, analogs & derivatives, therapeutic use)
- Skin Diseases, Infectious
(drug therapy, etiology)
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