Collagen XVII is expressed in human CNS neurons.

Abstract

Type XVII collagen (collagen XVII) is a component of hemidesmosomes, which connect epithelial cells to the underlying basement membrane. Previously, an association has been suggested between neurological disorders and the skin disease bullous pemphigoid, where autoimmunity is directed against collagen XVII. Furthermore, the lack of alpha6 integrin, a ligand of collagen XVII, has been implicated in defects of cortical organization in the mouse brain. In this study, we demonstrate for the first time the presence of collagen XVII in neurons of the human brain by in situ hybridisation, immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). We propose that collagen XVII may be involved in the pathogenesis of various disorders affecting neuronal migration or synaptic plasticity.

• Authors: Allan Seppänen, Helena Autio-Harmainen, Irina Alafuzoff, Terttu Särkioja, Johanna Veijola, Tiina Hurskainen, Leena Bruckner-Tuderman, Kaisa Tasanen, Kari Majamaa
• Journal: Matrix biology : journal of the International Society for Matrix Biology (Matrix Biol) Vol. 25 Issue 3 Pg. 185-8 (Apr 2006) ISSN: 0945-053X [Print] Netherlands
• PMID: 16387484 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantigens
• Non-Fibrillar Collagens

Topics

• Adult
• Aged
• Animals
• Autoantigens (analysis, genetics)
• Central Nervous System (cytology)
• Female
• Humans
• Male
• Mice
• Middle Aged
• Molecular Sequence Data
• Neurons (chemistry, cytology)
• Non-Fibrillar Collagens (analysis, genetics)
• Collagen Type XVII