Posttransplantation diabetes mellitus: prevalence and risk factors.

Abstract

BACKGROUND:

Prevalence of diabetes mellitus (DM) type 2 in Asturias is 10%. The associations between age, family history of diabetes, hypertension, obesity, hypertriglyceridemia, and development of type 2 diabetes are well established. The aim of this study was to evaluate the prevalence of and risk factors for posttransplantation diabetes mellitus (PTDM).

METHODS:

We retrospectively studied 500 patients who had received a cadaveric renal transplant. Subjects with pretransplantation diabetes (5.6% type 1 and 7% type 2) and nondiabetics (78.2%) were excluded. We only evaluated 46 (9.2%) patients with PTDM. The follow-up period was 6 months to 15 years. We reviewed gender, age, family history of diabetes, body weight, hypertension, cardiovascular events, serum creatinine, hepatitis C virus infection, triglycerides, hyperuricemia, high-density lipoprotein and low-density lipoprotein cholesterol, and immunosuppressive therapies.

RESULTS:

The median time to diagnosis of PTDM was 3 months (range 1-56 months) after transplantation, a period in which 47% patients developed this complication. Compared with nondiabetics, PTDM patients were significantly older (P = .000), more obese (P = .002), received tacrolimus (P = .027), and had hypertension (P = .014) or cardiovascular events (P = .000). Serum creatinine and hepatitis C virus infection rated were similar in both groups. On multivariate analyses, the risk factors significantly associated with the development of PTDM were greater age (P = .0024), obesity (P = .0032), and hypertension (P = .0516).

CONCLUSIONS:

Half of the patients with PTDM developed new-onset diabetes within the first 3 months. Age, obesity, and hypertension were among the risk factors for diabetes posttransplantation. After the transplantation, the modifiable risk factors are control of body weight and control of hypertension.

• Authors: J Baltar, T Ortega, F Ortega, A Laures, P Rebollo, E Gomez, J Alvarez-Grande
• Journal: Transplantation proceedings (Transplant Proc) Vol. 37 Issue 9 Pg. 3817-8 (Nov 2005) ISSN: 0041-1345 [Print] United States
• PMID: 16386548 (Publication Type: Journal Article)

Topics

• Diabetes Mellitus (epidemiology, genetics)
• Follow-Up Studies
• Humans
• Immunosuppression Therapy (methods)
• Kidney Transplantation (adverse effects)
• Male
• Middle Aged
• Multivariate Analysis
• Obesity (epidemiology)
• Postoperative Complications (epidemiology)
• Prevalence
• Regression Analysis
• Retrospective Studies
• Risk Factors
• Spain (epidemiology)
• Time Factors