Cytotoxic constituents from the whole plant of Corydalis pallida.

Abstract

Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 microg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.

• Authors: Hyang Rim Kim, Hye-Young Min, Yeon Hee Jeong, Sang Kook Lee, Nam Sook Lee, Eun-Kyoung Seo
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 28 Issue 11 Pg. 1224-7 (Nov 2005) ISSN: 0253-6269 [Print] Korea (South)
• PMID: 16350845 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Indicators and Reagents
• Berberine

Topics

• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Berberine (pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Corydalis (chemistry)
• Drug Screening Assays, Antitumor
• Humans
• Indicators and Reagents
• Magnetic Resonance Spectroscopy