Acute erosive gastritis induced by aspirin, ketoprofen, ibuprofen, and naproxen: its prevention by metiamide and cimetidine.

Abstract

Aspirin, ketoprofen, ibuprofen, and naproxen all produced acute gastric erosions in rats. Aspirin produced significantly more erosions than ketoprofen, ibuprofen, or naproxen. There was no significant difference between the effects of ketoprofen, ibuprofen, and naproxen. Aspirin and naproxen produced a synergistic effect at higher dosage. Metiamide and cimetidine were effective in preventing this type of experimental acute erosive gastritis.

• Authors: N S Mann, A J Sachdev
• Journal: Southern medical journal (South Med J) Vol. 70 Issue 5 Pg. 562-4 (May 1977) ISSN: 0038-4348 [Print] United States
• PMID: 16348 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Guanidines
• Histamine H2 Antagonists
• Imidazoles
• Metiamide
• Naproxen
• Ketoprofen
• Thiourea
• Aspirin
• Ibuprofen

Topics

• Acute Disease
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Aspirin (adverse effects)
• Gastric Mucosa (drug effects)
• Gastritis (chemically induced, pathology, prevention & control)
• Guanidines (therapeutic use)
• Histamine H2 Antagonists (therapeutic use)
• Ibuprofen (adverse effects)
• Imidazoles (therapeutic use)
• Ketoprofen (adverse effects)
• Male
• Metiamide (therapeutic use)
• Naproxen (adverse effects)
• Rats
• Thiourea (analogs & derivatives)