Colony-stimulating factor-1 in immunity and inflammation.

Abstract

Colony-stimulating factor-1 (CSF-1, also known as macrophage-CSF) is the primary regulator of the survival, proliferation, differentiation and function of mononuclear phagocytes. Studies that involve CSF-1-deficient mice demonstrate that there is a variable requirement for CSF-1 in the development of individual mononuclear phagocyte populations. However, these cells uniformly express the CSF-1 receptor, and their morphology, phagocytosis and responsiveness to infectious and non-infectious stimuli is regulated by CSF-1. CSF-1 plays important roles in innate immunity, cancer and inflammatory diseases, including systemic lupus erythematosus, arthritis, atherosclerosis and obesity. In several conditions, activation of macrophages involves a CSF-1 autocrine loop. In addition, secreted and cell-surface isoforms of CSF-1 can have differential effects in inflammation and immunity.

• Authors: Violeta Chitu, E Richard Stanley
• Journal: Current opinion in immunology (Curr Opin Immunol) Vol. 18 Issue 1 Pg. 39-48 (Feb 2006) ISSN: 0952-7915 [Print] England
• PMID: 16337366 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Macrophage Colony-Stimulating Factor

Topics

• Animals
• Humans
• Inflammation (immunology)
• Macrophage Activation (immunology)
• Macrophage Colony-Stimulating Factor (physiology)
• Phagocytes (immunology)