Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.

Abstract	In a retrospective analysis of 24 children with refractory or multiply relapsed acute lymphoblastic leukemia (ALL), a salvage regimen comprising amsacrine, etoposide, and high-dose methylprednisolone AEP achieved a significant treatment response in 11 of 19 evaluable patients (8 complete and 3 partial remissions). Five of 9 AEP-responsive patients who underwent subsequent stem cell transplantation are alive (median follow-up: 43 months; range 10 to 91). The load of minimal residual disease prior to transplantation appears to be predictive for outcome in this very poor-prognosis subgroup of ALL.
Authors	Martin A Horstmann, Wolf-Achim Hassenpflug, Udo zur Stadt, Gabi Escherich, Gritta Janka, Hartmut Kabisch
Journal	Haematologica (Haematologica) Vol. 90 Issue 12 Pg. 1701-3 (Dec 2005) ISSN: 1592-8721 [Electronic] Italy
PMID	16330449 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
Chemical References	Recombinant Proteins Amsacrine Cytarabine Deoxycytidine Granulocyte Colony-Stimulating Factor Vinblastine Etoposide Topotecan Dexamethasone Thiotepa Vidarabine Filgrastim Methylprednisolone Idarubicin
Topics	Adolescent Amsacrine (administration & dosage) Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use) Child Child, Preschool Combined Modality Therapy Cytarabine (administration & dosage) Deoxycytidine (administration & dosage, analogs & derivatives) Dexamethasone (administration & dosage) Drug Evaluation Drug Synergism Etoposide (administration & dosage) Female Filgrastim Granulocyte Colony-Stimulating Factor (administration & dosage) Humans Idarubicin (administration & dosage) Infant Leukemia-Lymphoma, Adult T-Cell (drug therapy, surgery) Male Methylprednisolone (administration & dosage) Neoplasm, Residual Peripheral Blood Stem Cell Transplantation Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, surgery) Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, mortality, pathology, surgery) Prognosis Recombinant Proteins Remission Induction Retrospective Studies Salvage Therapy Survival Analysis Thiotepa (administration & dosage) Topotecan (administration & dosage) Treatment Outcome Vidarabine (administration & dosage, analogs & derivatives) Vinblastine (administration & dosage, analogs & derivatives)

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