CARD games between virus and host get a new player.

Abstract

A growing family of cellular proteins encoding the caspase activation and recruitment domain (CARD) has a crucial role in immunity by sensing virus infection and signaling antiviral immune defenses. Four independent studies have identified a novel CARD-containing protein, variously called IPS-1, MAVS, VISA and Cardif, which is an essential signaling adaptor of the host defense mediating CARD-CARD interactions with retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDAS), sensors of virus infection. Disruption of this novel signaling pathway by hepatitis C virus (HCV) might provide a foundation for viral persistence.

• Authors: Cynthia L Johnson, Michael Gale Jr
• Journal: Trends in immunology (Trends Immunol) Vol. 27 Issue 1 Pg. 1-4 (Jan 2006) ISSN: 1471-4906 [Print] England
• PMID: 16309964 (Publication Type: Journal Article)

Chemical References

• Caspases

Topics

• Animals
• Caspases (metabolism)
• Enzyme Activation
• Humans
• Mitochondria (metabolism)
• Models, Biological
• Signal Transduction
• Virus Diseases (enzymology, virology)