Abstract | OBJECTIVE: METHODS AND RESULTS: Two hundred and twenty six individuals with established hypertension (diastolic pressure > 95mmHg) were from European Lacidipine Study on Atherosclerosis. Antibodies of IgG and IgM subclass were tested by ELISA against PC (aPC), cupper-oxidized (ox)- or malondialdehyde (MDA)-modified LDL. High-sensitivity C-reactive protein was measured by nephelometry. As a surrogate measure of atherosclerosis, we used the mean of the maximum intima-media thicknesses (IMT) in the far walls of common carotids and bifurcations was determined by ultrasonography at the time of enrolment, and 4 years following enrolment. aPC could be competed out by PC and OxLDL, while cardiolipin (CL) and beta2-glycoprotein I (beta2GPI) were less effective and phosphatidylserine (PS) not at all. Increases in IMT at follow-up were less common in subjects which at the time of enrolment had high IgM aPC (both 75th and 90th; odds ratios: 0.46; CI: 0.25-0.85; 0.36; CI: 0.15-0.87) and high IgM aOxLDL and aMDA- LDL (90th; odds ratios 0.27; p = 0.01; CI: 0.11-0.69 and 0.27; p = 0.01; CI: 0.11-0.69). CRP was unrelated to IMT-changes. The relationship between IgM aPC, aOxLDL and aMDA- LDL and changes in IMT was independent of age, treatment with atenolol or lacidipine, smoking and lipids. Women had higher levels of IgM antibodies tested (p < 0.05). CONCLUSIONS:
|
Authors | Jun Su, Anastasia Georgiades, Ruihua Wu, Thomas Thulin, Ulf de Faire, Johan Frostegård |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 188
Issue 1
Pg. 160-6
(Sep 2006)
ISSN: 0021-9150 [Print] Ireland |
PMID | 16307748
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Cardiolipins
- Immunoglobulin M
- Lipoproteins, LDL
- beta 2-Glycoprotein I
- oxidized low density lipoprotein
- Phosphorylcholine
- Malondialdehyde
|
Topics |
- Cardiolipins
(immunology)
- Carotid Artery Diseases
(diagnosis, immunology)
- Carotid Artery, Common
(diagnostic imaging, pathology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Hypertension
(complications, immunology)
- Immunoglobulin M
(blood, immunology)
- Lipoproteins, LDL
(immunology)
- Male
- Malondialdehyde
(immunology)
- Oxidation-Reduction
- Phosphorylcholine
(immunology)
- Prognosis
- Tunica Intima
(diagnostic imaging, pathology)
- Ultrasonography
- beta 2-Glycoprotein I
(immunology)
|