Role of leukotrienes in gastric mucosal injury induced by ischemia-reperfusion in rats.

Abstract

This study was designed to clarify the role of leukotrienes (LTs) in gastric injury induced by ischemia-reperfusion in rats. Gastric lesions were produced by clamping of the celiac artery and by reoxygenation following clamping. Administration of AA-861, a lipoxygenase inhibitor, significantly inhibited the increase in the total area of the gastric erosions and the increase in thiobarbituric acid-reactive substances in the gastric mucosa. Administration of YM-638, a peptide LT antagonist, showed protective effects similar to AA-861. These results suggest that the protective effects of AA-861 and YM-638 against ischemia-reperfusion-induced gastric injury were due to their antioxidative action.

• Authors: T Yoshikawa, H Ichikawa, Y Naito, M Kondo
• Journal: Journal of clinical gastroenterology (J Clin Gastroenterol) Vol. 14 Suppl 1 Pg. S68-70 ( 1992) ISSN: 0192-0790 [Print] United States
• PMID: 1629580 (Publication Type: Journal Article)

Chemical References

• Benzoquinones
• Leukotrienes
• Lipoxygenase Inhibitors
• Thiadiazoles
• Thiobarbiturates
• YM 16638
• 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone
• thiobarbituric acid

Topics

• Animals
• Benzoquinones (pharmacology)
• Gastric Mucosa (blood supply, drug effects, physiopathology)
• Leukotrienes (physiology)
• Lipid Peroxidation (drug effects)
• Lipoxygenase Inhibitors (pharmacology)
• Male
• Rats
• Rats, Inbred Strains
• Reperfusion Injury (physiopathology)
• Thiadiazoles (pharmacology)
• Thiobarbiturates (metabolism)