Abstract |
Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of production of G-CSF, GM-CSF and IL-6. Uterine cervical carcinoma with granulocytosis as a paraneoplastic syndrome, however, has been rarely reported. We recently witnessed a case of invasive squamous cell carcinoma of the uterine cervix with granulocytosis. Leukocytosis developed up to 69,000/microL, and then normalized after chemo- radiotherapy. There was no evidence of infection, tumor necrosis, glucocorticoid administration, or myeloproliferative disease by examination of a bone marrow aspirate when granulocytosis appeared. This phenomenon was probably associated with the secretion of hematopoietic growth factors such as G-CSF, GM-CSF and IL-6 by the tumor. We suggest that, like some other solid tumors, cervical cancer can present with granulocytosis as a paraneoplastic syndrome.
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Authors | Heui June Ahn, Yeon Hee Park, Yoon Hwan Chang, Sun Hoo Park, Min-Suk Kim, Baek Yeol Ryoo, Sung Hyun Yang |
Journal | The Korean journal of internal medicine
(Korean J Intern Med)
Vol. 20
Issue 3
Pg. 247-50
(Sep 2005)
ISSN: 1226-3303 [Print] Korea (South) |
PMID | 16295785
(Publication Type: Case Reports, Journal Article)
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Topics |
- Female
- Granulocytes
(pathology)
- Humans
- Leukocytosis
(etiology)
- Middle Aged
- Paraneoplastic Syndromes
(etiology)
- Uterine Cervical Neoplasms
(complications, diagnosis, physiopathology)
- Uterine Neoplasms
(complications, diagnosis)
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