Abstract |
There is a growing body of evidence that the advanced glycation end product (AGE)-their receptor (RAGE) system plays a central role in the pathogenesis of diabetic vascular complication. The renin-angiotensin system (RAS) contributes to the development and progression of diabetic angiopathy as well. However, the cross-talk between the AGE-RAGE system and the RAS is not fully understood. In this study, we examined the role of angiotensin II (Ang II) type 1 receptor system for RAGE expression in cultured endothelial cells (ECs) and in patients with essential hypertension. Ang II up-regulated RAGE mRNA levels of microvascular ECs and subsequently increased the soluble form of RAGE (sRAGE) expression in the medium of ECs, both of which were completely blocked by telmisartan, a commercially available Ang II type 1 receptor antagonist. Furthermore, telmisartan was found to decrease serum levels of sRAGE in patients with essential hypertension. These results demonstrate that sRAGE is released from the cell surface of Ang-II-exposed ECs. Our present study indicates that a cross-talk exists between the AGE-RAGE system and the RAS and suggests that serum levels of sRAGE may reflect endothelial RAGE expression.
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Authors | Kazuo Nakamura, Sho-Ichi Yamagishi, Yayoi Nakamura, Katsuhiko Takenaka, Takanori Matsui, Yuko Jinnouchi, Tsutomu Imaizumi |
Journal | Microvascular research
(Microvasc Res)
Vol. 70
Issue 3
Pg. 137-41
(Nov 2005)
ISSN: 0026-2862 [Print] United States |
PMID | 16271939
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Antioxidants
- Benzimidazoles
- Benzoates
- DNA Primers
- RNA, Messenger
- Receptor for Advanced Glycation End Products
- Receptors, Immunologic
- Angiotensin II
- Telmisartan
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Topics |
- Administration, Oral
- Age Factors
- Aged
- Angiotensin II
(metabolism)
- Angiotensin II Type 1 Receptor Blockers
(pharmacology)
- Antioxidants
(metabolism)
- Benzimidazoles
(pharmacology)
- Benzoates
(pharmacology)
- Blotting, Western
- Coronary Artery Disease
(blood, metabolism)
- DNA Primers
(chemistry)
- Disease Progression
- Endothelial Cells
(cytology)
- Endothelium, Vascular
(metabolism)
- Female
- Humans
- Hypertension
- Male
- Microcirculation
- Middle Aged
- Oxidative Stress
- RNA, Messenger
(metabolism)
- Receptor for Advanced Glycation End Products
- Receptors, Immunologic
(blood, metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Telmisartan
- Time Factors
- Up-Regulation
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