Abstract | OBJECTIVE: METHOD: The marker/haplotype associations obtained in a subset of 173 bipolar affective disorder patients with psychotic features were similar to those in the overall patient group, suggesting that stratification on the basis of psychotic features in general might be too crude a procedure. The authors therefore tested whether confining caseness to specific psychotic features would improve detection of genotype-phenotype correlations. RESULTS: In a logistic regression, "persecutory delusions" were found to be the only significant explanatory variable for the DAOA/G30 risk genotype among 21 OPCRIT symptoms of psychosis. The authors therefore tested for association between DAOA/G30 and bipolar affective disorder in the 90 cases with a history of persecutory delusions. Whereas this subset showed strong association (odds ratio=1.83 for the best marker), the remaining larger sample of 165 patients with no such history did not differ from comparison subjects, suggesting that the association between DAOA/G30 and bipolar affective disorder is due to persecutory delusions. This was confirmed in an independent study of 294 bipolar affective disorder patients and 311 comparison subjects from Poland, in which an association between bipolar affective disorder and DAOA/G30 was only seen when case definition was restricted to cases with persecutory delusions. CONCLUSIONS:
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Authors | Thomas G Schulze, Stephanie Ohlraun, Piotr M Czerski, Johannes Schumacher, Layla Kassem, Monika Deschner, Magdalena Gross, Monja Tullius, Vivien Heidmann, Svetlana Kovalenko, Rami Abou Jamra, Tim Becker, Anna Leszczynska-Rodziewicz, Joanna Hauser, Thomas Illig, Norman Klopp, Stefan Wellek, Sven Cichon, Fritz A Henn, Francis J McMahon, Wolfgang Maier, Peter Propping, Markus M Nöthen, Marcella Rietschel |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 162
Issue 11
Pg. 2101-8
(Nov 2005)
ISSN: 0002-953X [Print] United States |
PMID | 16263850
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carrier Proteins
- DAOA protein, human
- Genetic Markers
- Intracellular Signaling Peptides and Proteins
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Topics |
- Adult
- Bipolar Disorder
(classification, genetics, psychology)
- Carrier Proteins
(genetics)
- Chromosome Mapping
- Chromosomes, Human, Pair 13
(genetics)
- Delusions
(classification, diagnosis, genetics)
- Female
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Intracellular Signaling Peptides and Proteins
- Logistic Models
- Male
- Middle Aged
- Molecular Biology
(methods)
- Paranoid Disorders
(classification, diagnosis, genetics)
- Phenotype
- Schizophrenia
(genetics)
- Schizophrenic Psychology
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