A randomized trial of clinician-delivered interventions promoting barrier contraception for sexually transmitted disease prevention.

Abstract

OBJECTIVE:

The objective of this study was to compare 2 interventions promoting condoms and vaginal microbicides to prevent sexually transmitted disease (STD).

STUDY:

Women (N = 427) attending an STD clinic were randomly assigned to 2 clinician-delivered interventions and followed up monthly to assess condom/microbicide use and incidence of gonorrhea, chlamydia, and syphilis.

RESULTS:

During follow up, condom use rates were 69% (enhanced) and 49% (basic) and microbicide use rates were 44% and 29%, respectively. STD rates did not significantly differ between intervention groups. Perfect condom use (regardless of intervention arm) was associated with a 3-fold decrease in STD rates (relative risk [RR], 0.3; 95% confidence interval [CI], 0.1-0.8). Using a vaginal microbicide during > or =50% of the acts of intercourse was associated with reduced STD rates (RR, 0.5; 95% CI, 0.3-1.0) across intervention groups and condom use categories.

CONCLUSIONS:

The enhanced intervention increased use of condoms and vaginal microbicide; however, STD rates did not decrease because a protective effect was seen only among perfect barrier users, and the enhanced intervention only modestly increased perfect use.

• Authors: Lynn Artz, Maurizio Macaluso, Jareen Meinzen-Derr, Joseph Kelaghan, Harland Austin, Michael Fleenor, Edward W Hook 3rd, Ilene Brill
• Journal: Sexually transmitted diseases (Sex Transm Dis) Vol. 32 Issue 11 Pg. 672-9 (Nov 2005) ISSN: 0148-5717 [Print] United States
• PMID: 16254541 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents, Local

Topics

• Administration, Intravaginal
• Adult
• Anti-Infective Agents, Local (administration & dosage)
• Condoms (statistics & numerical data)
• Contraception, Barrier (methods, statistics & numerical data)
• Female
• Humans
• Male
• Patient Education as Topic (methods)
• Physician's Role
• Prospective Studies
• Safe Sex
• Sexual Behavior
• Sexually Transmitted Diseases (epidemiology, prevention & control)
• Treatment Outcome
• Videotape Recording