Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells.

Abstract	We have investigated the cytoprotective effect of eckol, which was isolated from Ecklonia cava, against oxidative stress induced cell damage in Chinese hamster lung fibroblast (V79-4) cells. Eckol was found to scavenge 1,1-diphenyl-2-picrylhydrazyl radical, hydrogen peroxide (H(2)O(2)), hydroxy radical, intracellular reactive oxygen species (ROS), and thus prevented lipid peroxidation. As a result, eckol reduced H(2)O(2) induced cell death in V79-4 cells. In addition, eckol inhibited cell damage induced by serum starvation and radiation by scavenging ROS. Eckol was found to increase the activity of catalase and its protein expression. Further, molecular mechanistic study revealed that eckol increased phosphorylation of extracellular signal-regulated kinase and activity of nuclear factor kappa B. Taken together, the results suggest that eckol protects V79-4 cells against oxidative damage by enhancing the cellular antioxidant activity and modulating cellular signal pathway.
Authors	Kyoung Ah Kang, Kyoung Hwa Lee, Sungwook Chae, Rui Zhang, Myung Sun Jung, Youngki Lee, So Young Kim, Hee Sun Kim, Hong Gu Joo, Jae Woo Park, Young Min Ham, Nam Ho Lee, Jin Won Hyun
Journal	FEBS letters (FEBS Lett) Vol. 579 Issue 28 Pg. 6295-304 (Nov 21 2005) ISSN: 0014-5793 [Print] England
PMID	16253238 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Dioxins Free Radical Scavengers Reactive Oxygen Species Transcription Factor RelA eckol Catalase Extracellular Signal-Regulated MAP Kinases
Topics	Animals Catalase (drug effects) Cell Line Cricetinae Dioxins (isolation & purification, pharmacology) Extracellular Signal-Regulated MAP Kinases (drug effects) Fibroblasts (drug effects, enzymology) Free Radical Scavengers (isolation & purification, pharmacology) Lipid Peroxidation (drug effects) Lung (cytology) Oxidative Stress (drug effects) Phaeophyta (chemistry) Phosphorylation (drug effects) Reactive Oxygen Species (metabolism) Transcription Factor RelA (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!