Pleomorphic carcinoma of the lung with mediastinal extension following malignant lymphoma: report of a case.

Abstract

In following up a patient with non-Hodgkin's lymphoma, we encountered a case of pulmonary pleomorphic carcinoma with mediastinal direct invasion. A 65-year-old man with hemoptysis was found to have an abnormal shadow in the right upper lung field. A 6.4 x 4.8-cm tumor adjacent to the upper mediastinum occupied the right anterior segment of the upper lobe (S3) and invaded the superior vena cava (SVC). The serum level of neuron-specific enolase was elevated to 11.9 ng/ml. A specimen from a transbronchial lung biopsy of the right B3b bronchus revealed giant tumor cells. A right upper lobectomy with SVC reconstruction was performed. The resected tumor was diagnosed as a pulmonary pleomorphic carcinoma with a large component of giant and spindle cells, and it is considered to be a rare histologic type.

• Authors: Takahiro Nakajima, Toshihiko Iizasa, Akira Iyoda, Kenzo Hiroshima, Kazuhiro Yasufuku, Masako Chiyo, Takashi Anayama, Hidemi Suzuki, Kiyoshi Shibuya, Hidemi Ohwada, Takehiko Fujisawa
• Journal: Surgery today (Surg Today) Vol. 35 Issue 11 Pg. 968-71 ( 2005) ISSN: 0941-1291 [Print] Japan
• PMID: 16249854 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Carcinoma (diagnosis, pathology, surgery)
• Carcinoma, Giant Cell (diagnosis, pathology, surgery)
• Humans
• Lung Neoplasms (diagnosis, pathology, surgery)
• Lymphatic Metastasis
• Lymphoma, Non-Hodgkin
• Male
• Neoplasm Invasiveness
• Neoplasms, Second Primary (diagnosis)
• Vascular Neoplasms (pathology, secondary, surgery)
• Vena Cava, Superior