Abstract |
Twelve patients with a high suspicion of brain metastases by previous clinical or radiologic examinations were studied in a phase III investigation with magnetic resonance (MR) imaging at 1.5 T after a bolus intravenous injection of 0.1 mmol/kg gadoteridol followed at 30 minutes by a second bolus injection of 0.2 mmol/kg gadoteridol. All lesions were best demonstrated (showed greatest enhancement) at the 0.3-mmol/kg (cumulative) dose, with image analysis confirming signal intensity enhancement in the majority of cases after the second gadoteridol injection. More lesions were detected with the 0.3-mmol/kg dose than with the 0.1-mmol/kg dose, and more lesions were detected with the 0.1-mmol/kg dose than on precontrast images. In this limited clinical trial, high-dose gadoteridol injection (0.3-mmol/kg cumulative dose) provided improved lesion detection on MR images specifically in intracranial metastatic disease.
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Authors | V M Runge, J E Kirsch, V J Burke, A C Price, K L Nelson, G S Thomas, B L Dean, C Lee |
Journal | Journal of magnetic resonance imaging : JMRI
(J Magn Reson Imaging)
1992 Jan-Feb
Vol. 2
Issue 1
Pg. 9-18
ISSN: 1053-1807 [Print] United States |
PMID | 1623287
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- Heterocyclic Compounds
- Organometallic Compounds
- gadoteridol
- Gadolinium
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Topics |
- Adult
- Aged
- Brain Neoplasms
(diagnosis, secondary)
- Contrast Media
- Female
- Gadolinium
- Heterocyclic Compounds
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Organometallic Compounds
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