Abstract | BACKGROUND: METHODS: RESULTS: Serum NTX correlated significantly with beta-CTX, PYD, DPD, BAP, and intact OC. NTX, as well as beta-CTX, PYD, DPD, BAP, and intact OC, correlated significantly with BMD at the time of measurement. NTX, beta-CTX, and DPD correlated significantly with the annual change in BMD during the 2-year period thereafter, in contrast to PYD, BAP, and intact OC. Patients in the highest quartile of serum NTX concentrations showed the fastest rate of bone loss. The sensitivity and specificity for detecting rapid bone loss were 48% and 83%, respectively, for serum NTX. CONCLUSION: Serum NTX may provide a clinically relevant serum assay to estimate bone turnover in HD patients.
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Authors | Yoshifumi Maeno, Masaaki Inaba, Senji Okuno, Tomoyuki Yamakawa, Eiji Ishimura, Yoshiki Nishizawa |
Journal | Clinical chemistry
(Clin Chem)
Vol. 51
Issue 12
Pg. 2312-7
(Dec 2005)
ISSN: 0009-9147 [Print] England |
PMID | 16223890
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Collagen Type I
- Peptides
- collagen type I trimeric cross-linked peptide
- Collagen
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Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Bone Resorption
(blood)
- Collagen
(blood)
- Collagen Type I
- Humans
- Middle Aged
- Peptides
(blood)
- Renal Dialysis
- Sensitivity and Specificity
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