TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.
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| Abstract |
T cell immunoglobulin-domain and mucin-domain (TIM) proteins constitute a receptor family that was identified first on kidney and liver cells; recently it was also shown to be expressed on T cells. TIM-1 and -3 receptors denote different subsets of T cells and have distinct regulatory effects on T cell function. Ferritin is a spherical protein complex that is formed by 24 subunits of H- and L-ferritin. Ferritin stores iron atoms intracellularly, but it also circulates. H-ferritin, but not L-ferritin, shows saturable binding to subsets of human T and B cells, and its expression is increased in response to inflammation. We demonstrate that mouse TIM-2 is expressed on all splenic B cells, with increased levels on germinal center B cells. TIM-2 also is expressed in the liver, especially in bile duct epithelial cells, and in renal tubule cells. We further demonstrate that TIM-2 is a receptor for H-ferritin, but not for L-ferritin, and expression of TIM-2 permits the cellular uptake of H-ferritin into endosomes. This is the first identification of a receptor for ferritin and reveals a new role for TIM-2.
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| Authors | Thomas T Chen, Li Li, Dong-Hui Chung, Christopher D C Allen, Suzy V Torti, Frank M Torti, Jason G Cyster, Chih-Ying Chen, Frances M Brodsky, Eréne C Niemi, Mary C Nakamura, William E Seaman, Michael R Daws |
| Journal | The Journal of experimental medicine (J Exp Med) Vol. 202 Issue 7 Pg. 955-65 (Oct 03 2005) ISSN: 0022-1007 [Print] United States |
| PMID | 16203866 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.) |
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