Myocardial ischaemia and reperfusion injury: reactive oxygen species and the role of neutrophil.
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| Abstract |
A growing body of evidence suggests that oxygen radicals can mediate myocardial tissue injury during ischaemia and, in particular, during reperfusion. This review focuses on the role of neutrophil as a mediator of myocardial damage. Upon reperfusion, neutrophils accumulate and produce an inflammatory response in the myocardium that is responsible, in part, for the extension of tissue injury associated with reperfusion. It has shown that the inhibition of neutrophil accumulation and adhesion is associated with decreased infarct size. This strongly suggests that myocardial cells at risk region undergo irreversible changes upon reperfusion and accumulation of neutrophils. Several pharmacological agents (ibuprofen, allopurinol, prostacyclin, and prostaglandin E analogues) protect the myocardium from reperfusion injury. In addition, the mechanisms by which these agents act and directions of research that may lead to therapeutically useful approaches are also discussed in this review.
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| Authors | Sheikh Arshad Saeed, Muhammad Anwar Waqar, Akbar Jaleel Zubairi, Hadi Bhurgri, Abdullah Khan, Saqib Ali Sikander Gowani, Saima N Waqar, M Iqbal Choudhary, Saima Jalil, Ali Hyder Zaidi, Iffat Ara |
| Journal | Journal of the College of Physicians and Surgeons--Pakistan : JCPSP (J Coll Physicians Surg Pak) Vol. 15 Issue 8 Pg. 507-14 (Aug 2005) ISSN: 1022-386X [Print] Pakistan |
| PMID | 16202368 (Publication Type: Journal Article, Review) |
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