The
polyol isomalt (
Palatinit) is a well established
sugar replacer. The impact of regular
isomalt consumption on metabolism and parameters of gut function in nineteen healthy volunteers was examined in a randomised, double-blind, cross-over trial with two 4-week test periods. Volunteers received 30 g
isomalt or 30 g
sucrose daily as part of a controlled diet. In addition to clinical standard diagnostics,
biomarkers and parameters currently discussed as risk factors for CHD, diabetes or
obesity were analysed. Urine and stool Ca and
phosphate excretions were measured. In addition, mean transit time, defecation frequency, stool consistency and weight were determined. Consumption of test products was affirmed by the urinary excretion of
mannitol. Blood
lipids were comparable in both phases, especially in volunteers with hyperlipidaemia, apart from lower
apo A-1 (P=0.03) for all subjects. Remnant-like particles, oxidised
LDL,
NEFA,
fructosamine and
leptin were comparable and not influenced by
isomalt. Ca and
phosphate homeostasis was not affected. Stool frequency was moderately increased in the
isomalt phase (P=0.006) without changes in stool consistency and stool water. This suggests that
isomalt is well tolerated and that consumption of
isomalt does not impair metabolic function or induce
hypercalciuria. In addition, the study data indicate that
isomalt could be useful in improving bowel function.