[Fenspiride in patients with acute bronchitis].

Abstract

UNLABELLED:

Fenspiride is an anti-inflammatory drug that may have a role in inhibition of histamine receptor H1 and influence a production of archidonic acid metabolites.

AIM:

The efficacy and tolerance of fenspiride therapy have been performed in patients with acute bronchitis.

MATERIAL AND METHODS:

597 patients, 51% females and 49% males, aged 39+/-18 years, were observed because of acute bronchitis. Fenspiride (Eurespal, Servier) was given in a dose of 240 mg per day (80 mg three times daily) for 14 consecutive days. During two following medical examinations - after 7 and 14 days of treatment, clinical symptoms of disease, therapy efficacy and tolerance were determined.

RESULTS:

Mean duration of acute bronchitis before fenspiride therapy was 2.3+/-1.3 days. In most of the patients (72%) a moderate, and in 27% mild degree of disease was diagnosed. Only 1% of patients were diagnosed as severe. Total evaluation of fenspiride efficacy in examined patients with acute bronchitis showed complete relief of symptoms after 7 days of therapy in 24% and after 14 days in 87% of patients. In 6% of patients after 7 days and in 1% after 14 days of fenspiride therapy no improvement was obtained. 28 adverse reactions were determined in 26 patients (4.3%): vertigo in 7, nausea in 6, somnolence in 5, palpitations in 4, fatigue in 2, abdominal pain in 2 and other symptoms in 2 patients. In 8 patients the therapy was discontinued after 7 days because of adverse reactions.

CONCLUSIONS:

In performed observations in patients with acute bronchitis the high clinical efficacy of fenspiride therapy. In 12% of patients an antibiotic support was necessary to obtain relief of the symptoms. Very good tolerance of the 14 days therapy was determined and it is recommended for safe clinical application.

• Authors: Tadeusz Płusa, Agnieszka Ochwat
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 19 Issue 109 Pg. 32-6 (Jul 2005) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Fenspiryd w leczeniu chorych na ostre zapalenie oskrzeli.
• PMID: 16194023 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Spiro Compounds
• fenspiride

Topics

• Acute Disease
• Adolescent
• Adult
• Anti-Inflammatory Agents (administration & dosage, adverse effects, therapeutic use)
• Bronchitis (drug therapy)
• Child
• Drug Administration Schedule
• Female
• Humans
• Male
• Middle Aged
• Spiro Compounds (administration & dosage, adverse effects, therapeutic use)
• Time Factors
• Treatment Outcome