Abstract |
Since the discovery of sumatriptan, several 5-HT(1D/1B) receptor agonists have now reached the clinic and marketplace as treatments for migraine. The highly efficacious F-11356 is the latest compound to emerge but none of these agents have appreciable selectivity between the h5-HT(1D) and h5-HT(1B) receptor subtypes. Research has now focused on obtaining selective h5-HT(1D) receptor agonists which, if inhibition of peptide release is involved in the antimigraine action, may be expected to have reduced vasoconstrictor liability. This has led especially to the discovery of L-775606 and PNU-109291, which should constitute useful tools to delineate the role of h5-HT(1D) receptors in migraine.
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Authors | M G Russell |
Journal | IDrugs : the investigational drugs journal
(IDrugs)
Vol. 2
Issue 1
Pg. 37-43
(Jan 1999)
ISSN: 1369-7056 [Print] England |
PMID | 16180169
(Publication Type: Journal Article)
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