Germline polymorphism of p53 codon 72 in gynecological cancer.

Abstract

OBJECTIVE:

To investigate the biological significance of single nucleotide polymorphism at codon 72 of the p53 gene in the development of gynecological cancer.

METHODS:

p53 codon 72 polymorphism was examined in a total of 354 blood samples from 95 normal, 83 cervical, 108 endometrial and 68 ovarian cancer cases using polymerase chain reaction and restriction fragment length polymorphism techniques.

RESULTS:

When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301). The Arg allele also increased the risk of endometrial cancer (OR = 1.42, 95% CI = 0.93 to 1.52) compared with the Pro allele, but no statistical difference was found (P = 0.1031). There was no significant difference in the genotype or allele prevalence between control subjects and cervical or ovarian cancer patients.

CONCLUSION:

Homozygous Arg at codon 72 of the p53 gene may be a risk factor for developing endometrial cancer in a Japanese population.

• Authors: Masatsugu Ueda, Yoshito Terai, Koji Kanda, Masanori Kanemura, Mikio Takehara, Hiroyuki Yamaguchi, Koji Nishiyama, Masayuki Yasuda, Minoru Ueki
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 100 Issue 1 Pg. 173-8 (Jan 2006) ISSN: 0090-8258 [Print] United States
• PMID: 16168468 (Publication Type: Journal Article)

Chemical References

• Codon

Topics

• Adult
• Aged
• Alleles
• Codon
• Female
• Genes, p53 (genetics)
• Genital Neoplasms, Female (genetics)
• Genotype
• Germ-Line Mutation
• Humans
• Middle Aged
• Polymorphism, Single Nucleotide
• Risk Factors