Abstract | PURPOSE: Expression of PTHrP is immunohistologically found in mammary tissues of all the normal cell, hyperplasia and malignant cell. In patients of breast cancer, positive ratio of PTHrP is reportedly 60-69%. Higher positive ratios of PTHrP are found in breast cancer showing bone metastasis than those without bone metastasis. And, breast cancer patients with PTHrP positive show poor prognosis suggesting a relationship to histological grade. Regarding PTHrP receptor, there is few report on its physiological role and relationship to other prognostic factors. The aim of this study was to determine the correlation between PTHrP receptor and various prognostic parameters of breast cancer patients with no axillary node metastasis. MATERIAL AND METHODS: RESULTS: CONCLUSIONS:
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Authors | Yasuhiro Suzuki, Yutaka Tokuda, Yuki Saito, Shinobu Umemura, Robert Yoshiyuki Osamura |
Journal | The Tokai journal of experimental and clinical medicine
(Tokai J Exp Clin Med)
Vol. 30
Issue 2
Pg. 127-32
(Jul 2005)
ISSN: 0385-0005 [Print] Japan |
PMID | 16146204
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Receptor, Parathyroid Hormone, Type 1
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Topics |
- Axilla
- Biomarkers
(analysis)
- Breast Neoplasms
(metabolism, pathology, surgery)
- Female
- Humans
- Immunohistochemistry
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Middle Aged
- Neoplasm Recurrence, Local
(pathology)
- Prognosis
- Receptor, Parathyroid Hormone, Type 1
(analysis, biosynthesis)
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