[The preliminary report of cervical cancer treated with californium-252 neutron after loading intracavitary radiotherapy].

Abstract

OBJECTIVE:

To observe the therapeutic effectiveness and complications of californium-252 (252Cf) brachytherapy in cervical cancer.

METHODS:

Fifty one cases of cervical cancer were diagnosed according to the standard of the International Federation of Gynecology and Obstetrics (FIGO), II a:8 cases, II b:31 cases, III a:8 cases, III b:4 cases. Treatment schedule: 252Cf after loading brachytherapy, 10-12 Gy/fraction/week, the total dose of reference point A was 36-40 Gy in three to four implant sessions. In the second day after 252Cf therapy, the whole pelvis was treated with 6 MV X-ray external beam radiotherapy, 200 cGy per fraction, 4 times per week. The total dose of external beam radiotherapy was 40 to 50 Gy (the middle of pelvis was blocked at width of 4 cm after 20-30 Gy), then the total dose of reference point B was 50-55 Gy;the total treatment time was 5-6 weeks.

RESULTS:

The average time of complete tumor regression was 25 days, the local control rate of 2 year was 100%, the total 2 year survival rate was 92%, i.e., II a: 8/8 cases, II b: 30/31 cases (97%), III a: 6/8 cases, III b: 3/4 cases; the late radiation complications of bladder and rectum was 2% respectively during these 2 years.

CONCLUSIONS:

It is concluded that combined 252 Cf brachytherapy and high energy X-ray external beam radiotherapy may be safe and effective in the management of cervical cancer. 252Cf has advantages of high local control rate; rapidly regression of bulky tumors and low-grade radiation complications.

• Authors: G Luo, C Zheng, J Shan
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 36 Issue 12 Pg. 742-4 (Dec 2001) ISSN: 0529-567X [Print] China
• PMID: 16136896 (Publication Type: English Abstract, Journal Article)

Chemical References

• Radioisotopes
• Californium

Topics

• Brachytherapy
• Californium (therapeutic use)
• Combined Modality Therapy
• Female
• Humans
• Radioisotopes (therapeutic use)
• Radiotherapy (adverse effects, methods)
• Survival Rate
• Treatment Outcome
• Uterine Cervical Neoplasms (mortality, radiotherapy)