Risk factors and outcomes of pancreatitis after open heart surgery.

Abstract

BACKGROUND:

We sought to analyze the risk factors and natural history associated with post-cardiac surgery acute pancreatitis.

METHODS:

Retrospective analysis of all patients having undergone cardiac surgery at our hospital between January 1, 1992, and October 1, 2001.

RESULTS:

A total of 10,249 cardiac operations were performed. Thirty-nine (0.4%) patients developed postoperative pancreatitis. There was a higher incidence during the period spanning 1992 through 1996 than 1997 through 2001 (0.6% versus 0.2%, P< .05). Patients with pancreatitis had longer postoperative length of stay (51+/-5 days versus 10+/-1 days, P<.05) and a greater in-hospital mortality rate (28% versus 4%, P<.05) than patients who did not develop pancreatitis. A history of alcohol abuse, cardiac surgery performed during 1992 to 1996, increased cardiopulmonary bypass time, and increased cross-clamp time were independent risk factors for the development of pancreatitis. Multiple-organ failure was an independent predictor for death among patients with pancreatitis.

CONCLUSIONS:

Although the frequency of post-cardiac surgery pancreatitis is diminishing, it is still associated with significant mortality.

• Authors: Alexander Perez, Hiromichi Ito, Robert S Farivar, Lawrence H Cohn, John G Byrne, James D Rawn, Sary F Aranki, Michael J Zinner, Nicholas L Tilney, David C Brooks, Stanley W Ashley, Peter A Banks, Edward E Whang
• Journal: American journal of surgery (Am J Surg) Vol. 190 Issue 3 Pg. 401-5 (Sep 2005) ISSN: 0002-9610 [Print] United States
• PMID: 16105526 (Publication Type: Journal Article)

Topics

• Acute Disease
• Aged
• Boston (epidemiology)
• Cardiac Surgical Procedures
• Female
• Humans
• Male
• Multivariate Analysis
• Pancreatitis (epidemiology, mortality)
• Postoperative Complications (epidemiology, mortality)
• Retrospective Studies
• Risk Factors