Abstract | BACKGROUND: METHODS AND RESULTS: Twelve patients with chronic obstructive lung disease and hypercapnic respiratory failure received nasal intermittent positive pressure ventilation at home during sleep. At six months eight were continuing with the ventilation. One patient had died and three had withdrawn because they were unable to sleep with the equipment. Full polysomnography performed during ventilation in patients continuing treatment at six months showed an increase in mean PaO2 of 11% (+2% to +23%) and lower mean transcutaneous carbon dioxide tensions (by -2.7 (-1.3 to -5.1) kPa) overnight compared with spontaneous breathing before the start of nasal intermittent positive pressure ventilation. Total sleep time and sleep efficiency changed during ventilation by +72.5 (+21 to +204) minutes and +5% (-3% to +30%) respectively; sleep architecture and the number of arousals were unchanged. Quality of life did not change but was no worse during ventilation. At one year seven patients were still using the ventilator and PaCO2 and bicarbonate ion concentration during the day had improved further by comparison with the values at six months (change from baseline -1.7 (-2.1 to -0.6) kPa, p less than 0.05, and -6.3 (-11.9 to -4) mmol/l, p less than 0.05). CONCLUSIONS:
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Authors | M W Elliott, A K Simonds, M P Carroll, J A Wedzicha, M A Branthwaite |
Journal | Thorax
(Thorax)
Vol. 47
Issue 5
Pg. 342-8
(May 1992)
ISSN: 0040-6376 [Print] England |
PMID | 1609376
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Female
- Home Nursing
- Humans
- Hypercapnia
(blood, therapy)
- Intermittent Positive-Pressure Ventilation
(methods)
- Lung Diseases, Obstructive
(blood, therapy)
- Male
- Middle Aged
- Oxygen
(blood)
- Quality of Life
- Respiratory Insufficiency
(blood, therapy)
- Sleep
(physiology)
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