Abstract | CONTEXT: OBJECTIVE: DESIGN, SETTING, AND PARTICIPANTS: MAIN OUTCOME MEASURES: RESULTS: During 2,900,463 person-years of follow-up, 84,317 cases of infectious disease hospitalization were identified. Out of 42 possible associations (6 vaccines and 7 infectious disease categories), the only adverse association was for Haemophilus influenzae type b vaccine and acute upper respiratory tract infection (rate ratio, 1.05; 95% confidence interval, 1.01-1.08 comparing vaccinated participants with unvaccinated participants). This one adverse association of 42 possible outcomes was within the limits of what would be expected by chance alone and the effect was not temporal or dose-response. When considering aggregated vaccine exposure, we found no adverse associations between an increasing number of vaccinations and infectious diseases. CONCLUSION:
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Authors | Anders Hviid, Jan Wohlfahrt, Michael Stellfeld, Mads Melbye |
Journal | JAMA
(JAMA)
Vol. 294
Issue 6
Pg. 699-705
(Aug 10 2005)
ISSN: 1538-3598 [Electronic] United States |
PMID | 16091572
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Child
- Communicable Diseases
(epidemiology, immunology)
- Confounding Factors, Epidemiologic
- Denmark
(epidemiology)
- Hospitalization
(statistics & numerical data)
- Humans
- Risk
- Vaccination
(adverse effects, methods, statistics & numerical data)
- Vaccines, Combined
(adverse effects, immunology)
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