Acitretin-induced enthesitis in a patient with psoriatic arthritis.

Abstract

A patient with psoriatic arthritis and cutaneous psoriasis took acitretin for 10 years to treat his skin lesions. Radiographs disclosed exuberant ossifications in several entheses. Their features were not typical for psoriatic arthritis but were consistent with acitretin-induced hyperostosis. Retinoids are known to induce hyperostosis, most notably when they are used in high dosages and over long periods. The concomitant presence of two conditions affecting the entheses may explain the exuberant nature of the ossifications in our patient.

• Authors: Véronique Vincent, Laurent Zabraniecki, Olivier Loustau, Bertrand Godfrin, Frédérique Bertrand Latour, Jean-Jacques Railhac, Bernard Fournié
• Journal: Joint bone spine (Joint Bone Spine) Vol. 72 Issue 4 Pg. 326-9 (Jul 2005) ISSN: 1297-319X [Print] France
• PMID: 16038845 (Publication Type: Case Reports, Journal Article)

Chemical References

• Keratolytic Agents
• Acitretin

Topics

• Acitretin (adverse effects, therapeutic use)
• Ankle Joint (diagnostic imaging)
• Arthritis, Psoriatic (diagnostic imaging, drug therapy)
• Arthrography
• Follow-Up Studies
• Humans
• Keratolytic Agents (adverse effects, therapeutic use)
• Ligaments, Articular (diagnostic imaging)
• Male
• Middle Aged
• Ossification, Heterotopic (chemically induced, diagnostic imaging)
• Tomography, X-Ray Computed