Gastric angiodysplasia in a child with Bernard-Soulier syndrome: efficacy of octreotide in long-term management.

Abstract

Gastrointestinal angiodysplasia in association with Bernard-Soulier syndrome has been previously described in adults. The authors report on a 14year-old boy presenting with massive upper gastrointestinal bleeding due to a large gastric angiodysplasia, in whom medical history and laboratory investigations were consistent with Bernard-Soulier syndrome. The vascular lesion was so widespread that surgical or endoscopic therapy was not considered. Therefore, treatment with octreotide, a somatostatin analog, was commenced, following a short course of tranexamic acid and proton pump inhibitor. During the 16-month follow-up with octreotide therapy, no occult or gross bleeding occurred. This case illustrates the utility of using octreotide for the long-term treatment of children with bleeding disorders and angiodysplasia.

• Authors: Zühre Kaya, Türkiz Gürsel, Buket Dalgic, Deniz Aslan
• Journal: Pediatric hematology and oncology (Pediatr Hematol Oncol) 2005 Apr-May Vol. 22 Issue 3 Pg. 223-7 ISSN: 0888-0018 [Print] England
• PMID: 16020106 (Publication Type: Case Reports, Journal Article)

Chemical References

• Octreotide

Topics

• Adolescent
• Angiodysplasia (complications, diagnosis, drug therapy)
• Bernard-Soulier Syndrome (complications, diagnosis, drug therapy)
• Endoscopy, Gastrointestinal
• Humans
• Male
• Octreotide (administration & dosage, therapeutic use)
• Stomach Diseases (complications, diagnosis, drug therapy)
• Time Factors
• Treatment Outcome