G protein beta 3 subunit gene variants and essential hypertension in the northern Chinese Han population.
|
| Abstract |
Recently a novel C825T polymorphism in the G protein beta3 subunit gene was identified that showed an association with hypertension in a German population; the results of studies in other populations have been inconsistent. To examine the contribution of GNB3 polymorphisms to the development of hypertension in the northern Chinese Han population, we conducted a case-control study consisting of 501 hypertensive cases and 503 controls using the G(-350)A, C825T and C1429T polymorphisms. Genotypes of samples were determined by PCR and restriction digestion. Single locus analysis showed a significant association between G(-350)A and hypertension (P = 0.01) but no association for C825T or C1429T. The three polymorphisms were in tight linkage disequilibrium (D'=-1 for G(-350)A-C825T, D'= 0.92 for C825T-C1429T) and a total of 7 haplotypes were observed in the entire population. Haplotype A-C-C was found to be significantly related to hypertension (P = 0.032) and A-C-C carriers had a more than two-fold higher risk of hypertension than non-carriers, after adjustment for BMI and glucose. In conclusion, our study suggests that G(-350)A is a potential functional polymorphism that may be related to hypertension, whereas the C825T and C1429T polymorphisms are not associated with hypertension in the northern Chinese Han population.
|
|---|---|
| Authors | Biao Li, Dongliang Ge, Yuelan Wang, Weiyan Zhao, Xiaoyang Zhou, Dongfeng Gu, Runsheng Chen |
| Journal | Annals of human genetics (Ann Hum Genet) Vol. 69 Issue Pt 4 Pg. 468-73 (Jul 2005) ISSN: 0003-4800 [Print] England |
| PMID | 15996174 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!