Abstract | BACKGROUND: OBJECTIVE: To evaluate the efficacy of ciclopirox 0.77% gel in the treatment of tinea pedis interdigitalis with secondary bacterial infection in a prospective, randomized, double-blind, placebo-controlled clinical study. SUBJECTS AND METHODS: One hundred subjects were enrolled in this 8-week study (twice-daily ciclopirox, 40 subjects; once-daily ciclopirox, 40 subjects; twice-daily vehicle, 20 subjects). Mycologic sampling, bacterial swabs, and evaluations for symptoms and signs of tinea pedis were performed on a target webspace at baseline and at weeks 2, 4, and 8. Global evaluations were made by both investigator and subject at each visit. RESULTS:
Ciclopirox gel applied once or twice daily significantly reduced the signs and symptoms at week 8, compared with vehicle (P<0.0036). The mycologic cure and complete cure rates were much higher for the ciclopirox regimens than for the vehicle regimen. Early reduction of bacterial counts was noted with the ciclopirox regimens. There was no significant difference in the adverse event rate between the ciclopirox groups and the placebo group. CONCLUSION:
|
Authors | Aditya K Gupta, Alayne R Skinner, Elizabeth A Cooper |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 44
Issue 7
Pg. 590-3
(Jul 2005)
ISSN: 0011-9059 [Print] England |
PMID | 15985032
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antifungal Agents
- Gels
- Pyridones
- Ciclopirox
|
Topics |
- Administration, Topical
- Anti-Bacterial Agents
(administration & dosage)
- Anti-Infective Agents
(administration & dosage)
- Antifungal Agents
(administration & dosage)
- Bacterial Infections
(complications, drug therapy)
- Ciclopirox
- Double-Blind Method
- Female
- Gels
(administration & dosage)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Pyridones
(administration & dosage)
- Tinea Pedis
(complications, drug therapy)
- Treatment Outcome
|