Abstract | BACKGROUND AND AIM: METHODS: RESULTS: There was no significant difference of their levels between the healthy control subjects and the patients before the treatment with interferon (55.9+/-21.8 microM vs. 60.9+/-30.0 microM). Their levels were determined at 2 weeks after the initiation of treatment with interferon and compared with those before the treatment in the patients with chronic hepatitis C. In the total patients treated, there was no significant difference between their levels before and at 2 weeks after the treatment (60.9+/-30.0 microM vs. 65.5+/-30.0 microM, P=0.14). However, when the levels were compared between sustained responders, in whom hepatitis C virus was eradicated, and non-responders, in whom the virus was not eradicated, the former had significantly higher levels of nitrite and nitrate than the latter at 2 weeks after the initiation of treatment (83.7+/-40.9 microM vs. 57.6+/-19.5 microM, P<0.01). The multivariate logistic regression analysis showed that the rise of nitrite and nitrate was an independent predictive factor for efficacy of interferon treatment. CONCLUSIONS:
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Authors | Atsushi Hokari, Mikio Zeniya, Hiroyasu Esumi, Tomohisa Ishikawa, Yukiko Kurasima, Gotaro Toda |
Journal | The Journal of infection
(J Infect)
Vol. 51
Issue 1
Pg. 47-53
(Jul 2005)
ISSN: 0163-4453 [Print] England |
PMID | 15979491
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- Interferon-alpha
- Nitrates
- Nitrites
- Nitric Oxide
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Topics |
- Adult
- Antiviral Agents
(therapeutic use)
- Female
- Hepatitis C, Chronic
(blood, drug therapy)
- Humans
- Interferon-alpha
(therapeutic use)
- Male
- Middle Aged
- Nitrates
(blood)
- Nitric Oxide
(physiology)
- Nitrites
(blood)
- Regression Analysis
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