One-week dual therapy with ranitidine bismuth citrate and clarithromycin for the treatment of Helicobacter pylori infection in Brazilian patients with peptic ulcer.

Abstract

AIM:

To assess the efficacy and safety of ranitidine bismuth citrate plus clarithromycin given for 1 wk in Brazilian patients with peptic ulcer.

METHODS:

One hundred and twenty patients with peptic ulcer were randomized in two treatment groups: (1) 1-wk regimen consisting of ranitidine bismuth citrate 400 mg b.i.d. with clarithromycin 500 mg b.i.d. or (2) 2-wk regimen of the same treatment. Eradication of the infection was considered when both the histologic examination and the urease test were negative for the infection 3 mo after treatment.

RESULTS:

By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively treated for 1 or 2 wk (P>0.05). By per protocol analysis, the eradication rates were 80% and 83%, respectively, in patients treated for 1 or 2 wk (P>0.05). Nine patients (8.2%) reported minor side effects.

CONCLUSION:

One-week therapy with ranitidine bismuth citrate and clarithromycin is safe, well tolerated and effective for treatment of H pylori infection, and appears to be comparable to the 2-wk regimen in terms of efficacy.

• Authors: Maria Aparecida Mesquita, Sonia Letícia Silva Lorena, Jazon Romilson Souza Almeida, Ciro Garcia Montes, Fábio Guerrazzi, Luciana T Campos, José Murilo Rubiota Zeitune
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 11 Issue 23 Pg. 3566-9 (Jun 21 2005) ISSN: 1007-9327 [Print] United States
• PMID: 15962376 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Anti-Ulcer Agents
• ranitidine bismuth citrate
• Ranitidine
• Clarithromycin
• Bismuth

Topics

• Adult
• Aged
• Anti-Bacterial Agents (therapeutic use)
• Anti-Ulcer Agents (therapeutic use)
• Bismuth (therapeutic use)
• Brazil
• Clarithromycin (therapeutic use)
• Drug Therapy, Combination
• Female
• Helicobacter Infections (drug therapy)
• Helicobacter pylori
• Humans
• Male
• Middle Aged
• Peptic Ulcer (drug therapy, microbiology)
• Ranitidine (analogs & derivatives, therapeutic use)
• Treatment Outcome