Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: Of the 377 men in the intent to treat population, including 197 treated with levofloxacin and 180 treated with ciprofloxacin, 35 on levofloxacin and 37 on ciprofloxacin with baseline PSA greater than 4 ng/ml were included in this analysis. Excluded from analysis were 2 levofloxacin treated patients with extremely high PSA at baseline (62 and 103 ng/ml, respectively). Mean baseline PSA +/- SD in the patients analyzed was 8.33 +/- 4.46 ng/ml, which decreased to 5.36 +/- 3.82 ng/ml after therapy. There was no significant difference in the mean change in PSA between the levofloxacin and ciprofloxacin groups. Approximately 42% of patients with increased baseline PSA had a post- therapy PSA of 4 ng/ml or less. Of patients who were microbiologically evaluable and had normalized PSA after therapy levofloxacin eradicated the pathogen in 90.9% (10 of 11). However, of patients in whom post- therapy PSA remained increased the microbiological eradication rate was 69.2% (9 of 13). Similarly 93.3% of the ciprofloxacin group (14 of 15 patients) with normalized post- therapy PSA experienced microbiological eradication compared with 61.5% (8 of 13) with continued increased PSA after therapy. CONCLUSIONS:
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Authors | Anthony J Schaeffer, Shu-Chen Wu, Alan M Tennenberg, James B Kahn |
Journal | The Journal of urology
(J Urol)
Vol. 174
Issue 1
Pg. 161-4
(Jul 2005)
ISSN: 0022-5347 [Print] United States |
PMID | 15947609
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Ciprofloxacin
- Levofloxacin
- Ofloxacin
- Prostate-Specific Antigen
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(pharmacology, therapeutic use)
- Anti-Infective Agents
(pharmacology, therapeutic use)
- Bacterial Infections
(blood, drug therapy)
- Chronic Disease
- Ciprofloxacin
(pharmacology, therapeutic use)
- Double-Blind Method
- Humans
- Levofloxacin
- Male
- Middle Aged
- Ofloxacin
(pharmacology, therapeutic use)
- Prostate-Specific Antigen
(blood)
- Prostatitis
(blood, drug therapy, microbiology)
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