Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection.

Abstract

The aim of the present study was to investigate, in 152 Spanish patients infected with hepatitis C virus (HCV), the possibility that killer cell immunoglobulin-like receptors (KIRs) influence progression to hepatocellular carcinoma. KIRs are related to the activation and inhibition of natural killer cells and may play an important role in the innate response against infection with such viruses as HCV. We found that the human leukocyte antigen-Bw4I80 epitope and the KIR3DS1 gene were more frequent in HCV carriers than in patients with hepatocellular carcinoma. Moreover, these associations were not independent of each other--the KIR3DS1/Bw4I80 genotype clearly was also more frequent in HCV carriers (odds ratio, 24.22).

• Authors: Antonio López-Vázquez, Luis Rodrigo, Jesus Martínez-Borra, Ramón Pérez, Manuel Rodríguez, Juan L Fdez-Morera, Dolores Fuentes, Sandra Rodríguez-Rodero, Segundo Gonzáez, Carlos López-Larrea
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 192 Issue 1 Pg. 162-5 (Jul 01 2005) ISSN: 0022-1899 [Print] United States
• PMID: 15942906 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Epitopes
• HLA-B Antigens
• HLA-Bw4 antigen
• Receptors, Immunologic
• Receptors, KIR
• Receptors, KIR3DS1

Topics

• Adult
• Aged
• Carcinoma, Hepatocellular (genetics, immunology)
• Disease Progression
• Epitopes (genetics)
• Female
• Genotype
• HLA-B Antigens (genetics)
• Hepatitis C (genetics, immunology)
• Humans
• Killer Cells, Natural (immunology)
• Liver Cirrhosis (immunology)
• Male
• Middle Aged
• Receptors, Immunologic (genetics)
• Receptors, KIR
• Receptors, KIR3DS1