[Adjuvant chemotherapy for Dukes B2 and C colon cancer combining 5-fluorouracil and folinic acid with or without carboplatin. Feasibility and comparison between standard and chronomodulated deliveries].

Abstract

Thirty-seven patients operated from a Dukes B2-C colon cancer were randomised to receive as adjuvant infusional chemotherapy, nine 5 FU and folinic acid courses with or without carboplatin, as standard (de Gramont; 2 days every 2 weeks) or chronomodulated administration (4 days every 2 weeks). The overall tolerance was judged excellent with less than 7% courses with dose-adaptations. The two carboplatin arms presented an enhanced haematological toxicity, while some more cutaneous toxicity was observed in the chronomodulated arm with the three drugs.

• Authors: C Focan, J Bury, G Matus, M P Graas, F Kreutz, L Longree, N Moeneclaey, A David, D Focan-Henrard
• Journal: Pathologie-biologie (Pathol Biol (Paris)) Vol. 53 Issue 5 Pg. 281-4 (Jun 2005) ISSN: 0369-8114 [Print] France
• Vernacular Title: Chimiothérapie adjuvante pour le cancer du colon de stades Dukes B2 et C comportant du 5-fluorouracile et de l'acide folinique, avec ou sans carboplatine. Faisabilité et comparaison d'une administration standard à une administration chronomodulée.
• PMID: 15939139 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Carboplatin
• Leucovorin
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use, toxicity)
• Carboplatin (administration & dosage, therapeutic use, toxicity)
• Chronobiology Phenomena
• Colonic Neoplasms (drug therapy)
• Drug Administration Schedule
• Female
• Fluorouracil (administration & dosage, therapeutic use, toxicity)
• Humans
• Leucovorin (administration & dosage)
• Male
• Middle Aged