Abstract |
Microsatellite instability (MSI) and p53 alterations which may represent major mechanisms of genetic instability, are rarely observed in de novo acute myeloid leukemia (AML) but may play a substantial role in subgroups characterized by either a myelodysplastic prephase (sAML), previous chemotherapy (tAML) or a complex aberrant karyotype. We performed allelotyping and p53 mutation analysis in 75 patients with morphologically and cytogenetically classified AML.
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Authors | Gerhard Herzog, Juxian Lu-Hesselmann, Yvonne Zimmermann, Torsten Haferlach, Wolfgang Hiddemann, Martin Dreyling |
Journal | Haematologica
(Haematologica)
Vol. 90
Issue 5
Pg. 693-5
(May 2005)
ISSN: 1592-8721 [Electronic] Italy |
PMID | 15921389
(Publication Type: Letter)
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Topics |
- Acute Disease
- Alleles
- Cell Transformation, Neoplastic
(genetics)
- Chromosome Aberrations
- Chromosomes, Human
(genetics, ultrastructure)
- Follow-Up Studies
- Genes, p53
- Genotype
- Humans
- Karyotyping
- Leukemia, Myeloid
(classification, genetics, mortality)
- Microsatellite Repeats
- Survival Analysis
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