5-Aminolevulinic acid-based photodynamic therapy for the treatment of two patients with extramammary Paget's disease.
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| Abstract |
Photodynamic therapy (PDT), which employs a combination of a tumor-localizing photosensitizer and visible light, has been used in the treatment of extramammary Paget's disease (EMPD). Two patients with EMPD were treated with PDT using 5-aminolevulinic acid (ALA). Histologically, in both cases, Paget's cells were present within the epidermis. Case 1 was a 92-year-old male who underwent total extirpation for treatment of EMPD. Two topical ALA-PDT treatments were applied to parts of the lesions at a total dose of 200J/cm2. Case 2 was a 73-year-old female, whose lesions in the right labia majora were treated with 3 topical ALA-PDT sessions at a total dose of 300 J/cm2. Clinical findings after the irradiation showed improvement in both patients, and elimination of tumor cells in the epidermis was confirmed histologically. Case 1 had no recurrence in the irradiation field at three months after PDT. Case 2 had a recurrence only in the periphery parts of the lesions at two months after PDT, but the periphery lesions remitted with two more PDT treatments. Topical ALA-PDT is an effective treatment for EMPD with tumor cells within the epidermis. It is noninvasive and achieves a cosmetically excellent outcome, especially in elderly patients and those in poor general condition.
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| Authors | Kiyomi Mikasa, Daisuke Watanabe, Chiharu Kondo, Miyuki Kobayashi, Hirono Nakaseko, Kazuhisa Yokoo, Yasuhiko Tamada, Yoshinari Matsumoto |
| Journal | The Journal of dermatology (J Dermatol) Vol. 32 Issue 2 Pg. 97-101 (Feb 2005) ISSN: 0385-2407 [Print] England |
| PMID | 15906538 (Publication Type: Case Reports, Journal Article) |
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