Abstract | OBJECTIVE: METHODS: RESULTS: Eight sera recognized a polypeptide of approximately 140 kd (CADM-140 autoantigen) by immunoprecipitation and immunoblotting. Immunoreactivity was detected in the cytoplasm, and indirect IF revealed a granular or reticular pattern. Anti-CADM-140 antibodies were detected in 8 of 42 patients with DM, but not in patients with other CTDs or IPF. Interestingly, all 8 patients with anti-CADM-140 antibodies had C-ADM. Among 42 patients with DM, those with anti-CADM-140 autoantibodies had significantly more rapidly progressive interstitial lung disease (ILD) when compared with patients without anti-CADM-140 autoantibodies (50% versus 6%; P = 0.008). CONCLUSION: These results indicate that the presence of anti-CADM-140 autoantibodies may be a novel marker for C-ADM. Further attention should be directed to the detection of rapidly progressive ILD in those patients with anti-CADM-140 autoantibodies.
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Authors | Shinji Sato, Michito Hirakata, Masataka Kuwana, Akira Suwa, Shinichi Inada, Tsuneyo Mimori, Takeji Nishikawa, Chester V Oddis, Yasuo Ikeda |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 52
Issue 5
Pg. 1571-6
(May 2005)
ISSN: 0004-3591 [Print] United States |
PMID | 15880816
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- CADM-140 peptide, human
- Intercellular Signaling Peptides and Proteins
- Peptides
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Topics |
- Adult
- Autoantibodies
(blood)
- Dermatomyositis
(immunology)
- Female
- Humans
- Intercellular Signaling Peptides and Proteins
- Japan
- Male
- Middle Aged
- Molecular Weight
- Peptides
(blood)
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