Abstract |
Qvar Autohaler efficacy on asthma control, assessed with E. Juniper asthma control questionnaire (ACQ), was compared with fluticasone and budesonide. An open randomized study, stratified (2:1) on the intake of long-acting beta2-mimetics (LAbeta2), was performed in patients with moderate to severe poorly controlled asthma (defined by at least one nocturnal discomfort in the last 5 days or a mean of 2 puffs of short-acting beta2-mimetics in the last 7 days or exercise dyspnea) despite treatment with beclomethasone < or = 1000 microg/day (or equivalent). 460 patients received Qvar Autohaler 800 microg/day (n = 149), fluticasone Diskus 1000 microg/day (n = 149) or budesonide Turbuhaler 1600 microg/day (n = 162) during 12 weeks. Asthma control improved in all groups, with no difference between groups. For patients treated with LAbeta2 (n = 286) a significantly greater improvement of the ACQ score was obtained with Qvar Autohaler versus fluticasone (1.0 +/- 1.0 vs. 0.6 +/- 0.9; P = 0.019), but not versus budesonide (0.9 +/- 0.9). Pulmonary function test improvements were similar in the 3 groups. The significant improvement in asthma control in patients receiving LAbeta2 suggests potential advantages for extrafine aerosols as part of anti-inflammatory treatment optimization.
|
Authors | Mathieu Molimard, Yan Martinat, Yves Rogeaux, Dominique Moyse, Jean-Yves Pello, Violaine Giraud |
Journal | Respiratory medicine
(Respir Med)
Vol. 99
Issue 6
Pg. 770-8
(Jun 2005)
ISSN: 0954-6111 [Print] England |
PMID | 15878495
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Aerosols
- Androstadienes
- Anti-Inflammatory Agents
- Bronchodilator Agents
- Ethanolamines
- Leukotriene Antagonists
- Budesonide
- Salmeterol Xinafoate
- Fluticasone
- Beclomethasone
- Albuterol
- Formoterol Fumarate
|
Topics |
- Administration, Inhalation
- Adult
- Aerosols
- Albuterol
(analogs & derivatives, therapeutic use)
- Androstadienes
(therapeutic use)
- Anti-Inflammatory Agents
(therapeutic use)
- Asthma
(drug therapy, physiopathology)
- Beclomethasone
(administration & dosage, therapeutic use)
- Bronchodilator Agents
(therapeutic use)
- Budesonide
(therapeutic use)
- Drug Administration Schedule
- Drug Therapy, Combination
- Ethanolamines
(therapeutic use)
- Female
- Fluticasone
- Formoterol Fumarate
- Humans
- Leukotriene Antagonists
(therapeutic use)
- Male
- Metered Dose Inhalers
- Middle Aged
- Particle Size
- Peak Expiratory Flow Rate
- Respiratory Function Tests
- Salmeterol Xinafoate
|