Obstetric outcome of patients with polycystic ovary syndrome treated by in vitro maturation and in vitro fertilization-embryo transfer.

Abstract

OBJECTIVE:

To assess the obstetric outcome of pregnancies resulting from in vitro maturation (IVM) and IVF-ET of immature oocytes retrieved from women with polycystic ovary syndrome (PCOS).

DESIGN:

Prospective observational study.

SETTING:

University fertility clinic.

PATIENT(S):

One hundred thirty-nine women undergoing 203 IVM treatment cycles.

INTERVENTION(S):

Immature oocyte recovery from unstimulated ovaries. In vitro oocyte maturation and fertilization. Fresh ET and assessment of obstetric outcomes in the pregnant women.

MAIN OUTCOME MEASURE(S):

Pregnancy and obstetric outcome.

RESULT(S):

Forty-one pregnancies were obtained in 187 ETs, resulting in a pregnancy rate of 21.9%. Except for three patients lost to follow-up in these pregnancies, the abortion and live birth rates were 36.8% (14 of 38) and 63.2% (24 of 38), respectively. The mean (+/-SD) gestational age and birth weight at delivery for singletons were 38.4 +/- 2.0 weeks (range, 33-41.6 weeks) and 3,252 +/- 516 g (1,750-4,100 g), respectively. For twins these were 36.7 +/- 1.9 weeks (34.6-39 weeks) and 2,361 +/- 304 g (1,900-2,990 g), respectively. Pregnancy complications occurred in five patients (13.2%); these included preterm labor (n = 3) and placenta previa (n = 2). Two patients (5.3%) had a major congenital anomaly diagnosed by ultrasonography.

CONCLUSION(S):

The abortion rate, gestational age and birth weight at delivery, and obstetric complications of pregnancies conceived by IVM-ET in women with PCOS were comparable with those of other women with PCOS being treated by conventional IVF-ET. In vitro maturation followed by IVF-ET seems to be a useful treatment option for women with PCOS, thus avoiding the risk of ovarian hyperstimulation syndrome.

• Authors: Kwang Yul Cha, Hyung Min Chung, Dong Ryul Lee, Hwang Kwon, Mi Kyung Chung, Lee Suk Park, Dong Hee Choi, Tae Ki Yoon
• Journal: Fertility and sterility (Fertil Steril) Vol. 83 Issue 5 Pg. 1461-5 (May 2005) ISSN: 1556-5653 [Electronic] United States
• PMID: 15866585 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Embryo Transfer (statistics & numerical data)
• Female
• Fertilization in Vitro (methods, statistics & numerical data)
• Humans
• Oocytes (physiology)
• Polycystic Ovary Syndrome (epidemiology, therapy)
• Pregnancy
• Pregnancy Outcome (epidemiology)
• Pregnancy Rate
• Prospective Studies