Abstract | PURPOSE: PATIENTS AND METHODS: Patients with operable breast cancer received C at 500 mg/m2, E at 100 mg/m2, and F at 500 mg/m2 every 21 days for 4 cycles followed by docetaxel at 75 mg/m2 every 21 days for 4 cycles. RESULTS: Of the 79 patients evaluable for analysis the median age was 46 years (28-59), and 61 patients (77.2%) had T2 tumors. A total of 312 of 316 (98.7%) cycles of CEF and 296 of 312 (94.9%) cycles of docetaxel were administered. Average total cumulative dose was 92% and 95% for CEF and docetaxel, respectively. The rate and grade of edema, neuropathy, arthralgia and myalgia were higher with docetaxel than with CEF. The overall clinical response rate was 70.9%. Breast conserving surgery was performed in 31 of 42 patients (73.8%) with a base-line tumor size of more than 3 cm. CONCLUSIONS:
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Authors | Hiroji Iwata, Seigo Nakamura, Masakazu Toi, Eisei Shin, Norikazu Masuda, Shinji Ohno, Yuichi Takatsuka, Kazufumi Hisamatsu, Kosuke Yamazaki, Mikihiro Kusama, Hiroshi Kaise, Yasuyuki Sato, Katsumasa Kuroi, Futoshi Akiyama, Hitoshi Tsuda, Masafumi Kurosumi, Japan Breast Cancer Research Group |
Journal | Breast cancer (Tokyo, Japan)
(Breast Cancer)
Vol. 12
Issue 2
Pg. 99-103
( 2005)
ISSN: 1340-6868 [Print] Japan |
PMID | 15858439
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study)
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Chemical References |
- Taxoids
- Docetaxel
- Epirubicin
- Cyclophosphamide
- Fluorouracil
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(drug therapy, pathology, surgery)
- Carcinoma
(drug therapy, pathology, surgery)
- Cyclophosphamide
(administration & dosage)
- Docetaxel
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Epirubicin
(administration & dosage)
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Mastectomy, Segmental
(statistics & numerical data)
- Middle Aged
- Neoadjuvant Therapy
- Taxoids
(administration & dosage)
- Treatment Outcome
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