Abstract | BACKGROUND: METHODS: Twenty-four spinal cord injury patients with neuropathic pain at or below the level of injury were randomized and completed a double-blind crossover trial of 5 mg/kg lidocaine and placebo infused over 30 min. Twelve patients reported evoked pain, and 12 patients had no evoked pain. Spontaneous and evoked pains were assessed using a visual analog scale and quantitative sensory testing. RESULTS:
Lidocaine significantly reduced spontaneous pain in all patients (P < 0.01) and in each of the two groups with (P < 0.01) and without (P = 0.048) evoked pain, with no difference in number of responders ( pain reduction > or = 33%) between the patients with (n = 6) and without (n = 5) evoked pain. Lidocaine significantly relieved both at-level and below-level neuropathic pain and decreased brush-evoked dysesthesia but not cold allodynia, pinprick hyperalgesia, or pain evoked by repetitive pinprick. CONCLUSIONS:
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Authors | Nanna B Finnerup, Fin Biering-Sørensen, Inger L Johannesen, Astrid J Terkelsen, Gitte I Juhl, Anders D Kristensen, Søren H Sindrup, Flemming W Bach, Troels S Jensen |
Journal | Anesthesiology
(Anesthesiology)
Vol. 102
Issue 5
Pg. 1023-30
(May 2005)
ISSN: 0003-3022 [Print] United States |
PMID | 15851891
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Local
- Lidocaine
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Topics |
- Adult
- Aged
- Anesthetics, Local
(administration & dosage, adverse effects, therapeutic use)
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Injections, Intravenous
- Lidocaine
(administration & dosage, adverse effects, therapeutic use)
- Male
- Middle Aged
- Neurons
(drug effects, physiology)
- Pain
(drug therapy, etiology)
- Pain Measurement
- Spinal Cord Injuries
(complications)
- Treatment Outcome
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