Abstract | BACKGROUND: METHODS: Fifty kidney and 25 liver recipients (aged 4 to 18 years) on triple immunosuppression, and 181 control children participated in the study for an average of 5.3 and 6.4 years after kidney and liver transplantation (range 1 to 11 years), respectively. Homeostasis model assessments for insulin resistance (HOMA) were calculated and fasting lipoprotein lipid profile, apolipoprotein A-I and B concentrations, LDL particle diameter, and indices of LDL susceptibility to copper-induced oxidation determined. RESULTS: Kidney patients had significantly higher serum total, high-density, and low-density lipoprotein cholesterol, triglyceride, apolipoprotein A-I and B concentrations than liver patients or control subjects (P < 0.003 for all). HOMA indices higher than the 95th percentile of Canadian normal children were seen in 50.0% of kidney (of liver 41.2%) recipients younger than 11 years, and in 27.3% of older recipients (of liver 37.5%). Smaller sized LDL or LDL of increased oxidizability was not more frequent in patients than in control children. CONCLUSION: Pediatric kidney recipients had significantly higher lipid and insulin concentrations than healthy control children. Combined hyperlipidemia and features of the dysmetabolic syndrome were common in children after kidney and liver transplantation. However, no small, dense LDL, or LDL prone to oxidation was seen in either group.
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Authors | Arja Siirtola, Marjatta Antikainen, Marja Ala-Houhala, Anna-Maija Koivisto, Tiina Solakivi, Suvi M Virtanen, Hannu Jokela, Terho Lehtimäki, Christer Holmberg, Matti K Salo |
Journal | Kidney international
(Kidney Int)
Vol. 67
Issue 5
Pg. 2046-55
(May 2005)
ISSN: 0085-2538 [Print] United States |
PMID | 15840056
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Lipids
- Lipoproteins, LDL
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Topics |
- Adolescent
- Blood Glucose
(metabolism)
- Case-Control Studies
- Child
- Child, Preschool
- Cross-Sectional Studies
- Female
- Humans
- Hypertriglyceridemia
(blood, etiology)
- In Vitro Techniques
- Insulin Resistance
- Kidney Transplantation
(adverse effects, physiology)
- Lipids
(blood)
- Lipoproteins, LDL
(blood, chemistry)
- Liver Transplantation
(adverse effects, physiology)
- Male
- Oxidation-Reduction
- Particle Size
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