Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata.

Abstract

We have demonstrated that serum macrophage migration inhibitory factor (MIF) was significantly elevated in patients with extensive alopecia areata (AA). Recently, functional polymorphisms have been identified in the MIF promoter region. To address the functional and prognostic relevance of the -173G/C and -794[CATT]5-8 repeat polymorphisms in MIF genes in patients with extensive AA, 113 patients with extensive AA and 194 healthy controls were genotyped. We found that MIF-173*C was a risk factor for early onset (<20 years) of extensive AA (odds ratio for GC heterozygotes with -173G/C was 4.88 (95% CI, 2.04-11.8), P=0.00038; odds ratio for CC homozygotes with -173G/C was 10.42 (95% CI, 2.56-43.5), P=0.0011). We found no statistically significant differences in the genotype frequencies of the -794[CATT]5-8 repeat polymorphism and extensive AA. These results suggest that polymorphisms within the MIF-173*C allele confer an increased risk of susceptibility to the extensive forms of AA, especially with an early onset of disease. MIF is therefore suggested to be closely implicated in the pathogenesis of the more extensive forms of AA.

• Authors: T Shimizu, N Hizawa, A Honda, Y Zhao, R Abe, H Watanabe, J Nishihira, M Nishimura, H Shimizu
• Journal: Genes and immunity (Genes Immun) Vol. 6 Issue 4 Pg. 285-9 (Jun 2005) ISSN: 1466-4879 [Print] England
• PMID: 15815686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Macrophage Migration-Inhibitory Factors

Topics

• Adolescent
• Adult
• Aged
• Alleles
• Alopecia Areata (genetics, pathology)
• Child
• Child, Preschool
• Female
• Genetic Predisposition to Disease
• Humans
• Macrophage Migration-Inhibitory Factors (genetics)
• Male
• Microsatellite Repeats (genetics)
• Middle Aged
• Polymorphism, Single Nucleotide
• Promoter Regions, Genetic (genetics)
• Risk Factors