Abstract | OBJECTIVE: METHODS: Eighty-six central obese hypertensive patients (BMI = 39 +/- 5 kg/m(2), 84% of women, 48 +/- 8.5 years old) were placed on a hypocaloric diet and placebo therapy for 4 weeks. They were then randomized to receive sibutramine (10 mg) or placebo for 24 weeks. Both, before therapy and at the end of the study, the waist and hip circumferences were measured and the waist/hip ratio (WHR) was calculated; abdominal ultrasonography was performed in order to estimate the amount of subcutaneous fat (SF) and visceral fat (VF), and the visceral/subcutaneous ratio. Beyond HOMA-r, another insulin resistance index (IRIp) was calculated by means of the formula: peak of blood glucose after oral glucose load x plasma insulin level/10(4). Fasting plasma leptin and lipid levels were also determined. RESULTS:
Sibutramine induced greater weight reduction than placebo (6.7 vs. 2.5%, p < 0.001). Reductions in WHR (0.97 +/- 0.08 vs. 0.94 +/- 0.07, p < 0.01), IRIp (0.11 +/- 0.07 vs. 0.09 +/- 0.06 mmol mu/l(2)) and VF (6.4 +/- 2.4-6.0 +/- 2.4 cm, p < 0.01) were observed only with sibutramine. Plasma leptin decreased with placebo (24 +/- 15 vs. 18 +/- 10 UI/l, p < 0.01), but not with sibutramine (18.8 +/- 8.4 vs. 18.2 +/- 13.2 UI/l). No clinically significant change in lipid profile was observed in both groups. Moreover, office and 24-h blood pressure values did not change during placebo or sibutramine therapy, whereas a significant increase in office heart rate, from 78.3 +/- 7.3-82 +/- 7.9 b.p.m., p = 0.02, was observed with sibutramine. CONCLUSIONS:
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Authors | A N Faria, F F Ribeiro Filho, N E Kohlmann, S R Gouvea Ferreira, M T Zanella |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 7
Issue 3
Pg. 246-53
(May 2005)
ISSN: 1462-8902 [Print] England |
PMID | 15811141
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antihypertensive Agents
- Appetite Depressants
- Cyclobutanes
- Leptin
- Lipids
- sibutramine
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Topics |
- Adult
- Antihypertensive Agents
(therapeutic use)
- Appetite Depressants
(therapeutic use)
- Chi-Square Distribution
- Cyclobutanes
(therapeutic use)
- Drug Therapy, Combination
- Female
- Glucose Tolerance Test
- Humans
- Hypertension
(complications, drug therapy, metabolism)
- Insulin Resistance
- Leptin
(blood)
- Lipids
(blood)
- Male
- Middle Aged
- Obesity
(complications, drug therapy, metabolism)
- Waist-Hip Ratio
- Weight Loss
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