A specific COX-2 inhibitor attenuates cell infiltration but does not prolong graft survival in murine cardiac transplantation.

Abstract

COX-2 is a key factor in the progression of inflammation, the effects of a specific COX-2 inhibitor in cardiac transplantation have not yet been elucidated. To test the hypothesis that a COX-2 inhibitor can alter cardiac rejection, we analyzed graft survival using totally allomismatched grafts. Although the COX-2 inhibitor attenuated myocardial cell infiltration, the inhibitor did not prolong survival. We conclude that the COX-2 inhibition may have potential for the suppression of inflammation in cardiac allografts.

• Authors: M Ogawa, J Suzuki, N Koga, H Kosuge, M Isobe
• Journal: Transplantation proceedings (Transplant Proc) 2005 Jan-Feb Vol. 37 Issue 1 Pg. 121-2 ISSN: 0041-1345 [Print] United States
• PMID: 15808568 (Publication Type: Journal Article)

Chemical References

• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors
• Thiazines
• Thiazoles
• Cyclooxygenase 2
• Prostaglandin-Endoperoxide Synthases
• Meloxicam

Topics

• Animals
• Cyclooxygenase 2
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors (therapeutic use)
• Graft Survival (drug effects, immunology)
• Heart (drug effects)
• Heart Transplantation (immunology, pathology)
• Male
• Meloxicam
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Myocardium (pathology)
• Prostaglandin-Endoperoxide Synthases (metabolism)
• Thiazines (therapeutic use)
• Thiazoles (therapeutic use)
• Time Factors
• Transplantation, Homologous (immunology)